Lessons Learned/Sites of Reproblematization

“We are far from out of the woods” seems to be the mantra among the public health officials who have to speak to the public. But for right now, it seems clear that this round of H1N1 is not nearly as serious as many initially feared. In this light, I wanted to provoke all those of you following this more closely to brainstorm a bit about what exactly the “lessons learned” might be from this event for different experts and policymakers, and what, for us, are the emerging sites of reproblematization, where existing undersatndings and practice are called into question.

One possibility is that there will be a certain amount of derision about the level of alarm that was raised. But my sense is that this will mostly be limited to late night comedy and right wing talk.

Another possibility is that there will be intensive discussions about the issues that Carlo has been raising, concerning the relationship between the current “phase” definitions and levels of political and medical mobilization and response. As Carlo wrote:

One of the interesting questions is the following: If this virus (which we are not allowed to name anymore …) continues to circulate among humans, will the WHO announce phase 6, i.e. a full-scale pandemic? With a virus that seems to cause not much mortality, this will be a difficult question. I really doubt that they will announce phase 6, even if all the criteria of phase 6 are essentially met. The pandemic alert scheme might soon need extensive revision …

A third area of reflection might have to do with interpreting the performance of health authorities in Mexico and drawing conclusions for global health surveillance. It seems to me that the initial sense is that once the Government got into its disciplinary lockdown mode, it did pretty well. But it is also obvious that everyone would have liked for there to be more laboratory capacity right at the beginning, such that the case and death counts would not have been exaggerated at the beginning. Everyone knows that basic public health surveillance globally is crucial to a global health preparedness system, but investment in basic lab capacity is a different issue.

A fourth area has to do with the question of how seriously to take H1N1 moving forward, what measures to take in preparation for a more serious outbreak, and what measures to take to prevent such an outbreak. In the former case, one key question is obviously going to be vaccine development. My understanding is that there is no decision about whether to proceed, but I don’t understand what the issues are. In the latter case there may be a whole series of questions, such as farm biosecurity. I have heard that one of the major concerns is large-scale transmission to pigs (again) which would create conditions for recombination into more virulent forms.

Thoughts on these or others?

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2 Responses to Lessons Learned/Sites of Reproblematization

  1. Dale A. Rose says:

    I’ll tackle elements of the fourth area raised by Stephen from my own personal perspective, and not as an official view or statement of the CDC (sorry, I’ve gotta keep saying that…). The basic issue(s) here have to do with the vaccine development and manufacturing process for influenza vaccine, which is largely unchanged for quite some time now. Seed stock of target isolates predicted to have acceptable immunogenicity are developed (perhaps 4-8 week process), then handed over to private sector manufacturers for further development leading to clinical trials. Bracketing for the moment the peculiar challenges of manufacturing influenza vaccine in essentially chicken eggs, which may require manufacturers to start from square one if pilot lots do not meet quality standards (which does happen, leading to occasional shortages which I’m sure we all remember), these clinical trials need to demonstrate a sufficient degree of safety prior to manufacturing ramp up. Of course, manufacturing is a private sector activity and “responsibility” – although the latter term is used here in a proscribed manner. Manufacturers may, of course, choose *not* to manufacture a vaccine – unless they have contracted with a purchaser, such as the gov’t, to do so. So while there are certainly various understandings in place as to which manufacturers might take the lead in manufacturing (due in part to the market position and in-house expertise of some of them, including Sanofi Pasteur), there is nothing, per se, “given” about it. There has been no decision to “go ahead” with full scale vaccine production because we are not there in the process yet. However, a seed stock is in active development…

  2. Dale A. Rose says:

    Federal Response Stages for flu might also require a look-see: see here and you decide.

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